Endak Hydrochloride
Endak Hydrochloride - General Information
A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent. [PubChem]
Pharmacology of Endak Hydrochloride
Endak Hydrochloride is a beta1 and beta2 (non-selective) adrenergic receptor-blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Endak Hydrochloride, when applied topically to the eye, has the action of reducing elevated, as well as normal, intraocular pressure, whether or not accompanied by glaucoma. Elevated intraocular pressure is a major risk factor in the pathogenesis of glaucomatous visual field loss and optic nerve damage. Endak Hydrochloride reduces intraocular pressure with little or no effect on pupil size or accommodation in contrast to the miosis which cholinergic agents are known to produce.
Endak Hydrochloride for patients
Endak Hydrochloride Interactions
Ocupress should be used with caution in patients who are receiving a beta-adrenergic blocking agent orally because of the potential for additive effects on systemic beta-blockade.
Close observation of the patient is recommended when a beta-blocker is administered to patients receiving catecholamine-depleting drugs such as reserpine, because of possible additive effects and the production of hypotension and/or marked bradycardia, which may produce vertigo, syncope, or postural hypotension.
Endak Hydrochloride Contraindications
Ocupress Ophthalmic Solution is contraindicated in those individuals with bronchial asthma or with a history of bronchial asthma, or severe chronic obstructive pulmonary disease; sinus bradycardia; second- and t.i.d. degree atrioventricular block; overt cardiac failure ; cardiogenic shock; or hypersensitivity to any component of this product.
Additional information about Endak Hydrochloride
Endak Hydrochloride Indication: For the treatment of intraocular hypertension and chronic open-angle glaucoma
Mechanism Of Action: The primary mechanism of the ocular hypotensive action of carteolol in reducing intraocular pressure is most likely a decrease in aqueous humor production.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Carteolol
Synonyms: Carteololum [Inn-Latin]; Carteolol Hydrochloride; Carteolol HCl
Drug Category: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Antihypertensive Agents; Sympatholytics
Drug Type: Small Molecule; Approved
Other Brand Names containing Carteolol: Cartrol; Endak Hydrochloride; Ocupress;
Absorption: Not Available
Toxicity (Overdose): The most common effects expected with overdosage of a beta-adrenergic blocking agent are bradycardia, bronchospasm, congestive heart failure and hypotension.
Protein Binding: Not Available
Biotransformation: Hepatic.
Half Life: Not Available
Dosage Forms of Endak Hydrochloride: Solution Ophthalmic
Chemical IUPAC Name: 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one
Chemical Formula: C16H24N2O3
Carteolol on Wikipedia: https://en.wikipedia.org/wiki/Carteolol
Organisms Affected: Humans and other mammals
